![]() Notable early clinical trial failures were especially devastating, including the death of Jessie Gelsinger and the development of leukaemia in numerous children as a result of treatments. Unfortunately, numerous clinical trial failures shattered this expectation early on, leaving the great potential of gene therapies as a cure-all for human genetic diseases unfulfilled.Īt the outset, the application of gene therapy technologies was expected to be straightforward, but tragically, we quickly realised that this was not necessarily true. The early years of gene therapy were characterised by an era of overwhelming optimism, with many believing that advances in DNA manipulation would mean the realisation of curative therapies for multiple disease states. Dr David Baram from gene therapy company EmendoBio provides a snapshot of the history of therapeutic genetic engineering.ĭr David Baram from gene therapy company EmendoBio provides a snapshot of the history of therapeutic genetic engineering, explaining the early pitfalls and reasons for recent renewed optimism.
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